South Africa's assumption of the G20 presidency on December 1, 2024, marked an important opportunity for the country, the continent and global South. This historic event, the first time an African nation leads this influential forum, holds the potential to reshape global financial architecture, geopolitical and multilateral institutional coordination, and sustainable and shared growth. It is a tangible opportunity to drive a progressive agenda onto the world stage, viewed through a uniquely African lens. South Africa, as the only African country with permanent membership in the G20, plays a vital role in integrating African priorities into global governance. Dr Mbuyiseni Ndlozi is joined by Ambassador Xolisa Mabhongo, Sous Sherpa, G20 Sherpa Office.