We hosted a roundtable with Criselda Kananda, Dr. Kate Rees, and Ndivhuwo Rambau to mark World AIDS Day 2025 under the theme “Overcoming Disruption: Transforming the AIDS Response.” The discussion highlighted funding and health-system challenges, the rollout of tools like lenacapavir, and the vital role of community advocacy and youth-focused strategies in sustaining South Africa’s HIV response.