What happens when chest pain persists, but standard tests offer no clear explanation? Lance Alexander speaks with Assoc Prof Angela Koh, Director, Cardiovascular Ageing and Longevity (CRANE) Programme, National Heart Centre Singapore to explore two diagnostic approaches at the National Heart Centre Singapore: functional coronary angiography, which investigates how the heart’s blood vessels work, and MOSAIC, which assesses the heart and muscles for early signs of decline. Who could benefit, what do the procedures involve, and how could the findings change treatment?