This Spanish explorer accompanied Christopher Columbus on his famous voyage, but he also came to search for a mysterious legend. This leads us to try to express grief in medical terms that even Dr Frank finds difficult to explain.

<p>This Spanish explorer accompanied Christopher Columbus on his famous voyage, but he also came to search for a mysterious legend. This leads us to try to express grief in medical terms that even Dr Frank finds difficult to explain.</p>

In Part One of each episode, Dr Frank will talk about a famous figure from history who suffered from an illness or had a disability. At that time, no-one knew or understood what may have caused the problem, or how to treat it - It was a mystery at the time. In Part Two of the episode, Dr Frank will discuss that same or similar illness or ailment in a modern-day context, and many times it has remained a mystery. Each two-part episode will be intriguing and informative.