The immune system is a complex network designed to protect our bodies from harmful invaders. But sometimes it can turn on us attacking our own cells and in doing so, causing autoimmune disease. Over the last 50 years, research into our immune system has advanced to identify particular drivers that protect us from autoimmune disease. Researchers are learning how these responses are tuned under various environmental and genetic circumstances. Professor Rob Brink is working to understand these fine-tuning aspects and how we can manipulate them through the advent of cheaper and faster DNA sequencing.

The immune system is a complex network designed to protect our bodies from harmful invaders. But sometimes it can turn on us attacking our own cells and in doing so, causing autoimmune disease. Over the last 50 years, research into our immune system has advanced to identify particular drivers that protect us from autoimmune disease. Researchers are learning how these responses are tuned under various environmental and genetic circumstances. Professor Rob Brink is working to understand these fine-tuning aspects and how we can manipulate them through the advent of cheaper and faster DNA sequencing.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

Medical Minds

Editing the immune system

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/45718d92-ac65-4dc0-8580-b00f01714edc/transcript

Arthritis affects millions of people, but the underlying causes are still not fully understood. What makes the immune system that normally protects us suddenly attack our joints? And why do arthritis flares seem to arrive without warning?

In this episode, we explore how certain immune cells or signals might be responsible for switching inflammation on.

We hear from Garvan's Dr Etienne Masle-Farquhar, who is mapping these processes in both rheumatoid arthritis and osteoarthritis, with the goal of predicting flares earlier and guiding more effective treatment.

Arthritis affects millions of people, but the underlying causes are still not fully understood. What makes the immune system that normally protects us suddenly attack our joints? And why do arthritis flares seem to arrive without warning?
In this episode, we explore how certain immune cells or signals might be responsible for switching inflammation on.
We hear from Garvan's Dr Etienne Masle-Farquhar, who is mapping these processes in both rheumatoid arthritis and osteoarthritis, with the goal of predicting flares earlier and guiding more effective treatment.

Arthritis: uncovering pathways to better treatment   

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/693e3518-8816-44e3-b70f-b3b00147ab9f/transcript

For decades, the fight against cancer has focused on killing the tumour cell. We treated cancer like an isolated entity that needed to be destroyed – but what if we’ve been looking at the wrong target?

In this episode, we delve into the critical insight that cancer is not just a rogue cell – it’s an entire ecosystem – and that ecosystem is the key to unlocking a new class of cures.

We hear from Garvan's Dr Ankur Sharma, who is using precision technology to dissect how the environment around liver cancers allows them to grow unchecked. The ultimate goal for this research is to develop better diagnostics and treatments for this deadly cancer.

For decades, the fight against cancer has focused on killing the tumour cell. We treated cancer like an isolated entity that needed to be destroyed &ndash; but what if we&rsquo;ve been looking at the wrong target?
In this episode, we delve into the critical insight that cancer is not just a rogue cell &ndash; it&rsquo;s an entire ecosystem &ndash; and that ecosystem is the key to unlocking a new class of cures.
We hear from Garvan's Dr Ankur Sharma, who is using precision technology to dissect how the environment around liver cancers allows them to grow unchecked. The ultimate goal for this research is to develop better diagnostics and treatments for this deadly cancer.

Liver cancer: discovering the next generation of therapy targets

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/e8a23dde-e99f-4d93-8323-b38d0189a6fd/transcript

Therapies and drugs have evolved enormously in the last 30 years. For example, in cancer, where previously our options were limited to surgery, chemotherapy and radiotherapy, we’re now hearing terms like cancer immunotherapy, targeted therapies and even cancer vaccines. Many of these are biologics.

In this episode you’ll hear from Dr Rachel Galimidi who is at the forefront of biologics drug development and is working to make new and better treatments for a range of diseases.

Therapies and drugs have evolved enormously in the last 30 years. For example, in cancer, where previously our options were limited to surgery, chemotherapy and radiotherapy, we&rsquo;re now hearing terms like cancer immunotherapy, targeted therapies and even cancer vaccines. Many of these are biologics.
In this episode you&rsquo;ll hear from Dr Rachel Galimidi who is at the forefront of biologics drug development and is working to make new and better treatments for a range of diseases.

Biologics- engineering tomorrow’s medicines

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/e1505154-eba4-47f6-b2a2-b37e00444206/transcript

Editing the immune system

In 1 playlist(s)

Medical Minds

Social links

Follow podcast

Recent clips