Our gastrointestinal system contains more than 70% of the body’s immune cells and can house more microbial cells than there are human cells in our entire body. Unravelling all that complexity is more important than ever, with conditions affecting the gut, such as Crohn’s and ulcerative colitis, on the rise. In today’s episode, we speak to Dr Kylie James who is taking a genetic deep dive – using single cell genomics – to develop more personalised approaches to preventing and treating inflammatory bowel disease. 

Our gastrointestinal system contains more than 70% of the body’s immune cells and can house more microbial cells than there are human cells in our entire body. Unravelling all that complexity is more important than ever, with conditions affecting the gut, such as Crohn’s and ulcerative colitis, on the rise. In today’s episode, we speak to Dr Kylie James who is taking a genetic deep dive – using single cell genomics – to develop more personalised approaches to preventing and treating inflammatory bowel disease.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

We dive deep into the minds of our amazing researchers to find out how they tick and how they are working to make our lives better.

Medical Minds

Can genomics help treat inflammatory bowel disease?

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/7f977d5e-3636-402c-9faf-b1e00033f68d/transcript

Autoimmune diseases affect one in eight people, yet many are still treated by suppressing the entire immune system. But what if all of them shared a common root cause – a small number of rogue immune cells that could be identified and removed?

In this episode, Garvan's Professor Chris Goodnow explains how he's tracking down these 'rogue clones', and how targeting them could pave the way for more effective treatments for autoimmune diseases.

Autoimmune diseases affect one in eight people, yet many are still treated by suppressing the entire immune system. But what if all of them shared a common root cause &ndash; a small number of rogue immune cells that could be identified and removed?
In this episode, Garvan's Professor Chris Goodnow explains how he's tracking down these 'rogue clones', and how targeting them could pave the way for more effective treatments for autoimmune diseases.

Finding the needle in the haystack

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/31c48c6e-4a68-4682-b5f5-b4db01789436/transcript

Pancreatic cancer can surround itself with dense scar tissue, creating a kind of fortress that makes tumours incredibly difficult to treat. So, how do we find a way through?

In this episode, Garvan researcher Dr Brooke Pereira explains the role of this complex tumour environment, and reveals how better understanding it could be the key to uncovering new treatment options.

Pancreatic cancer can surround itself with dense scar tissue, creating a kind of fortress that makes tumours incredibly difficult to treat. So, how do we find a way through?
In this episode, Garvan researcher Dr Brooke Pereira explains the role of this complex tumour environment, and reveals&nbsp;how better understanding it could be the key to uncovering new treatment options.

Storming the tumour fortress 

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/93317ee4-2f5e-4964-8fad-b4bb005b3150/transcript

Our immune system is like a well-trained security network, constantly scanning the body for threats. So, how is it that some harmful cells manage to slip by unnoticed?

In this episode, we speak to computational biologist, Dr Clare Puttick, about how cancer cells can evade detection by disrupting the molecular “flags” that would normally mark them for attack.

Her research is uncovering new ways to expose these hidden cells and could offer fresh insights into diseases where the immune system doesn’t behave as expected, including endometriosis.

 

Our immune system is like a well-trained security network, constantly scanning the body for threats. So, how is it that some harmful cells manage to slip by unnoticed?
In this episode, we speak to computational biologist, Dr Clare Puttick, about how cancer cells can evade detection by disrupting the molecular &ldquo;flags&rdquo; that would normally mark them for attack.
Her research is uncovering new ways to expose these hidden cells and could offer fresh insights into diseases where the immune system doesn&rsquo;t behave as expected, including endometriosis.
&nbsp;

Hunting hidden cells

https://api.omny.fm/orgs/acbb53f8-dca0-419a-b44f-af49001056ab/clips/a936857b-b908-45b7-a925-b46c017bc1e2/transcript

Can genomics help treat inflammatory bowel disease?

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