What does the insanity defense mean in a court of law? And is there such a thing as temporary insanity? Is the twinkie defense a real thing? Can someone use premenstrual syndrome as a defense? And what does the legal wrestling around insanity tell us about the differences between brains: yours and other people’s, or even yours one day and yours the next day? How does law comport with science, and how are they sometimes like two people with quite different ways of looking at the world? Join to find out what happened to Andrea Yates, how the legal system deals with mental illness, and so much more.