What do you want to know about the brain? What mysteries of human behaviour do you want to understand? And what incredible awards has How We're Wired won in the 13th Annual Lovies? In this special episode, Dr Anna Machin shares some good news, and asks a quick favour... Send questions to: wired@freshairproduction.co.uk How We're Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode. 

How do our brains get wired up in the womb? Why is it important that nerve cells find the correct partners to form connections? And how has our understanding of this vital process changed over the last 40 years? In this special episode, join evolutionary anthropologist Dr Anna Machin and producer Dr Eva Higginbotham as they uncover how our brains get wired up with Brain Prize 2023 winner Professor Christine Holt. Plus, hear them reflect on some of their favourite moments - and key takeaways - from the show. With special thanks to Christine Holt. How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.

How We're Wired season 1's final episode will be with you next week, but in the meantime, why not check out our sister podcast Ocean Matters? Our ocean is the earth's defining feature. But the blue of our blue planet is so much more than just a colour. It is rich with life and plays an important role in keeping our planet stable and healthy. Worryingly, we are seeing our ocean change, for the worse. In Ocean Matters, you can join oceanographer and physicist Dr Helen Czerski as she meets the scientists who are working to save our ocean and marine life in one of the most remote parts of our planet. Here you can listen to a clip as she takes us on a journey to the deep sea… How We're Wired and Ocean Matters are Fresh Air productions for The Bertarelli Foundation. Follow now so you never miss an episode.

What does it mean to be in a coma? How can we tell if someone on life support is actually conscious? And how can scientists use synchronised heart rhythms to predict which comatose patients are likely to wake up? In this focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the neuroscience of coma –  from the challenges in knowing for certain that someone isn't conscious, to novel techniques that might help families choose when to cease life support. With special thanks to Marzia De Lucia. How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.

What happens in our brains when we die? Where does consciousness come from? And what can out of body experiences teach us about how we create our own realities? In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience of death and consciousness, from brain activity  during near-death experiences, to the complexities of how we embody ourselves.  With special thanks to Gillian, Olaf Blanke, and Kevin Nelson. How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode

Why are some of us more susceptible to dementia? What is a 'Super Ager'? And what might help us protect our brains in later life?  In this focus episode of How We’re Wired join producer Dr Eva Higginbotham as she dives into the science of Super Agers, from the genes that increase your risk of Alzheimer's to the structural brain changes seen in those who have aged well, and  meeting a 92-year-old world traveller with a penchant for penguins.     With special thanks to Emily Rogalski and June Scott.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode 

How do our brains change as we get older? Why are we more likely to develop Alzheimer’s or experience a stroke late in life? And what can you do to help protect your neural health? In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience behind the mature brain, from the neural changes that makes most of us more forgetful, to strides in repairing brain tissue after stroke. With special thanks to Sue, Alexandra Touroutoglou, and Jocelyne Bloch. How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode. For information and support regarding stroke https://www.bhf.org.uk/informationsupport/conditions/stroke To listen to the Ticker Tapes podcast https://www.bhf.org.uk/informationsupport/support/podcasts

How do we recognise faces? What part of the brain helps us discern a stranger from a friend? And could you be a Super Recogniser?   In this focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the science of facial recognition, from face blindness to the brains of those who are exceptional at recalling faces, and the tests you can do to discover if you have the skill.  With special thanks to Josh Davis.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode 

How do we see? What parts of the brain are responsible for vision? And how can gene therapy restore sight to people living with a visual impairment?   In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience behind our sense of sight, from the complex computations of the retina to how gene therapy is revolutionising treatment for blindness.    With special thanks to Peter, Botond Roska, Bernard Schneider, and the Royal National Institute of the Blind.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How does stress affect decision-making? What does burnout do to the brain? And how can parents find ways to cope with emotional exhaustion and fatigue?   In this focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the neuroscience of burnout, from how brain cells lose connections during chronic stress, to why we evolved fight, flight or freeze. With special thanks Sascha, Siobhan, Ciara, Rachel, Amy Arnsten, and Kendra Wilde.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do our brains change when we become parents? What does having ‘baby brain’ really mean? And how can fathers use the science of bonding to feel close to their babies?  In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience of parenthood – from the evolution of how human parenting to why testosterone levels permanently drop in new fathers, and if there’s really a difference between Mum’s and Dad’s brain.    With special thanks to Adi Yaniv, Amy, Alex, and baby Frank.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How could virtual reality cure chronic pain? What’s happening the brain when we embody an avatar? And what complex conditions might benefit from experiencing bodily illusions?   In this focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the science of virtual reality and how it could change the lives of people suffering from complex chronic pain conditions.   With special thanks Jasmine Ho.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do we feel pain? What parts of the brain control our reaction to painful sensations? And how is stem cell technology revolutionising the search for better treatments for chronic pain?    In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience of pain – from how early pain experiences can make us at risk for future problems, to the complexity of treating life-changing pain conditions like fibromyalgia, and a new system for developing novel pain relievers.   With special thanks to Rachel, Andy, and Clifford Woolf.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How can some people taste sounds? What’s happening in the brain of those who feel other’s sensations as their own? And why might we have evolved some of these extraordinary abilities in the first place?   In this focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the science of synaesthesia – from a massage therapist who can ‘feel’ other people’s pain, to the neuroscience of ‘tasting’ words.   With special thanks CC Hart, James Wannerton, Michael Banissy, and Jamie Ward.       How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do we feel with our fingertips? What parts of the brain integrate the complexities of touch? And how are scientists creating prosthetics that give feeling back to amputees?  In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the neuroscience behind our sense of touch; from the complex web of nerve endings that cover our skin to meeting the first individuals to experience feeling with a prosthesis.  With special thanks to David Ginty, Dennis Aabo Sørensen, Loretana Puglisi, and Silvestro Micera.     How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do you know if your dog really loves you? What’s happening in a dog’s brain when they’re with their favourite human? And how can close human-dog bonds help people, and dogs, heal from trauma?   In this episode of How We’re Wired, join producer Dr Eva Higginbotham as she uncovers the history of the dog-human relationship; from scientific proof that our dogs love us to the genetics of dog sociability, and a look at the healing relationship between a dog and their person.  With special thanks to Beth, Emma the dog, and Clive Wynne      How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.   If you feel you need support, please contact your local crisis centre UK https://rapecrisis.org.uk/ USA https://www.rainn.org/ Switzerland https://www.rcne.com/contact/countries/switzerland/

What is love? What's happening in our brains when we're falling for someone? And why are we wired for forming deep, meaningful connections?  In this episode of How We’re Wired, join evolutionary anthropologist and love expert Dr Anna Machin as she unpicks the neuroscience of love, from the genetic unpinning of our strongest relationships to the neurochemicals that bond us together. Plus, the story of a couple facing the challenges of making long-distance love work.    With special thanks to Serafin, Megan, and Bianca Acevedo.     How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

What’s happening in our brains when we sleep? Why are autistic people more likely to struggle with sleep? And how might new sleep technology help improve memory?  In this episode of How We’re Wired, join producer Dr Eva Higginbotham as she looks at how autism affects sleep, and why devices that record brain activity could help autistic people get better rest, and everyone improve their ability to remember.   With special thanks to Dara Manoach and Brian Baxter.     How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode. 

What is autism? Why are autistic women and girls less likely to receive a diagnosis? And what does the science really say about the underlying causes of autism?   In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she explores autism, from the striking prevalence of eating disorders in autistic women and girls to the mental load of masking, and the relief one teen felt when she could finally be herself.     With special thanks to Lab, Will Mandy, and Florina Uzefovsky.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

What’s going through the mind of an Olympic rower at the starting line? Is an athlete’s brain all that different from a non-athlete? And what lessons can we all learn from a sports mind coach?  In this episode of How We’re Wired, join producer Dr Eva Higginbotham as she looks at the neuroscience and psychology of elite sport.   With special thanks to Frances Houghton, Mark Williams, and Don Macpherson.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do we move? What parts of the brain control how we use our muscles? And what implanted technology is allowing people with spinal cord injuries to walk again? In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she picks apart the neuroscience of movement, from how the brain orchestrates complex tasks like playing an instrument, to a visit with the first person with a complete spinal cord injury to walk.     With special thanks to Michel Roccati, Mackenzie Mathis, and Tomislav Milekovic. How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.

How common are mental health conditions in teenagers? How can depression look different in a child compared to an adult? And how are scientists using brain imaging studies to better understand conditions like schizophrenia?   In this episode of How We’re Wired, join producer Dr Eva Higginbotham as she looks at mental health in children and young adults, from important risk factors to mechanisms of anxiety. With special thanks to Ben Jacobs and Daniel Dickstein.      How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.   If you feel you need support, please contact your local crisis centre. UK https://www.mind.org.uk https://www.samaritans.org/ USA https://988lifeline.org/ Switzerland  https://www.parspas.ch/l-association

What’s going on in the brains of teenagers? How does puberty affect the brain? And why might changing the way we talk about teens lead to changes in their brain structure?    In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she picks apart the neuroscience of puberty and adolescence, from the brain regions responsible for bodily changes to the importance of teens taking risks.    With special thanks to resident pre-teen Kitty, Russell Romeo, and Eva Telzer.     How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

How do we taste? What evolutionary benefit is there to tasting bitter and sour? And why should you think about wearing noise-cancelling headphones on planes if you want to enjoy your food?    In this Focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she uncovers the neuroscience underpinning taste, from how you can optimise dishes using synergistic umami to a test to discover if you’re a supertaster.   With special thanks to Robert Parks and Barry Smith.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.

How do we smell? What role does our sense of smell play in our closest relationships? And how are brands creating scents to keep us coming back for more? In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she unpicks the science of smell, from how your sense of smell changes over your lifetime to a visit to a perfumer creating olfactory memories. With special thanks to Duncan Boak, Carl Philpott, and Dawn Goldworm.  How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode. https://www.fifthsense.org.uk/

Why does our memory sometimes fail us? Would you recognise an implanted memory? And what implications do the risks of false memories have for society?  In this Focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she explores the murky depths of our imperfect memories; from whether a brain scan can identify whether a memory is true or false to the potential for memory-numbing drugs as a treatment for PTSD.   With special thanks to Daniel Schacter.    How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Follow now so you never miss an episode.  

What is a memory made of? Which parts of the brain help us remember? And what can taxi drivers’ brains tell us about how memories are made?  In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she dives into the science of memory, and how we remember. We’ll unpick the structures of the brain that are involved in making memories, and attend an MRI scan of a London cabbie to understand what makes London drivers’ brains so fascinating to neuroscientists.   With special thanks to Mark, Stephanie, Amy Milton, and Hugo Spiers.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Subscribe or follow now so you never miss an episode.  

What’s it like to lose your hearing? Why is the cause of hearing loss often so hard to diagnose? And what innovative technologies might help scientists develop new therapies?   In this Focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she uncovers the complexities of hearing loss – from tinnitus to the mysteries of the inner ear – and speaks to a dancer who is having to learn to live with reduced hearing.   With special thanks to our guests Helen and Tina Stankovic.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Subscribe or follow now so you never miss an episode.  

How do we hear? What parts of our brain respond to sound? And how can we use vibrations to expand the way we enjoy music?   In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin on a sensory journey exploring the world of sound, and how we hear it. We’ll meet a dancer who remembers being able to hear clearly for the very first time, learn how our brains break down complex sound in a noisy environment, and experience a device which expands the pleasure we get from music.    With special thanks to David Corey, Daniel Huber, Mario Prsa, and Vita.  

How do we learn to talk? When do babies first understand language? And how do scientists study language learning in the lab?   In this Focus episode of How We’re Wired, join producer Dr Eva Higginbotham as she visits the Oxford Brookes Babylab to understand how babies make sense of what we say, including watching real-life language experiments with infants and trying to interview a 9-month-old.   With special thanks to Alice, her son, and Nayeli Gonzalez-Gomez.  How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Subscribe or follow now so you never miss an episode.  

What is the brain made of? How is it built in the womb? And what impact does preterm labour have on brain development?    In this episode of How We’re Wired, join evolutionary anthropologist Dr Anna Machin as she explores the beginnings of the human brain. We’ll visit an ultrasound clinic to observe foetal brain structures and hear how the earliest brain cells develop in the womb, plus visit a biotechnology lab in Switzerland working hard to protect immature brains.   With special thanks to Lisa Goodrich, David Baud, Erick Garcia Cordero, Loulia Kassem, Kristen, and Edel.   How We’re Wired is a Fresh Air Production for The Bertarelli Foundation. Subscribe or follow now so you never miss an episode. 

Love. Touch. Speech. Movement. Consciousness. What do they all have in common? From before birth to after death, our brains underpin our experiences and feelings. They make us who we are. But how? In How We’re Wired, evolutionary anthropologist Dr Anna Machin goes behind the scenes of cutting-edge of neuroscience research to uncover the fascinating stories of how our brains grow, change, and ultimately die. Together, we’ll meet the scientists exploding our understanding of how the brain works and head into labs developing life-changing technologies. From hormones to heartbreak, we’re exploring true, personal stories of people’s lives – and brains - from birth to death, taking a deep look at the science that explains us all. This is How We’re Wired from The Bertarelli Foundation. Subscribe or follow now for free, wherever you get your podcasts, so you never miss an episode.