If you’re worried about memory loss or have a family history of Alzheimer’s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer’s prevention and reversal—even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions.

In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer’s. They explore why cognitive decline is not inevitable and how Dr. Bredesen’s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now—and the tools have never been more accessible.


KEY TAKEAWAYS:


Alzheimer’s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline.


Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline.


Your Brain Runs on Supply & Demand: Cognitive health depends on supporting your brain’s high energy needs while reducing inflammatory load and toxic exposure.


Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear.


Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role.


GLP-1s and Alzheimer’s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people—especially APOE4 homozygotes.

 

TIMESTAMPS AND KEY TOPICS:
0:00 – Introduction

6:48 – Pathogens, toxins, and the real cause of Alzheimer’s

13:32 – Menopause, oestrogen, and female brain vulnerability

24:05 – Judy’s story: reversing cognitive decline for 13+ years

32:18 – Most common risky behaviours for brain degeneration

42:21 – Best exercises for insulin sensitivity and cognition

51:10 – Supplements that protect brain structure & function

54:22 – How to use The Ageless Brain as a practical guide

58:45 – Final thoughts + where to learn more from Dr. Bredesen

 

VALUABLE RESOURCES

Click here for discounts on all the products I personally use and recommend

 

A BIG thank you to our sponsors who make the show possible:

Get 20% off the Creatine I love at trycreate.co/ANGELA20, and use code ANGELA20 to save 20% on your firsts order.

Brain Boost: Try Neuro Regenerate at lvluphealth.com/angela and use code ANGELA15 to save 15%

ABOUT THE GUEST

Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline.

Dr Dale Bredesen’s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - https://amzn.eu/d/gdrjKQm

https://www.apollohealthco.com/

https://www.instagram.com/drdalebredesen/

https://www.facebook.com/drdalebredesen/   

ABOUT THE HOST

Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine.

Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out.

The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode.




CONTACT DETAILS

Instagram

Facebook

LinkedIn

Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show!

Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

If you&rsquo;re worried about memory loss or have a family history of Alzheimer&rsquo;s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer&rsquo;s prevention and reversal&mdash;even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions.
In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer&rsquo;s. They explore why cognitive decline is not inevitable and how Dr. Bredesen&rsquo;s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now&mdash;and the tools have never been more accessible.
 KEY TAKEAWAYS:
<ul data-start="1105" data-end="2197">
<li data-start="1105" data-end="1304">
Alzheimer&rsquo;s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline.
</li>
<li data-start="1424" data-end="1574">
Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline.
</li>
<li data-start="1575" data-end="1741">
Your Brain Runs on Supply &amp; Demand: Cognitive health depends on supporting your brain&rsquo;s high energy needs while reducing inflammatory load and toxic exposure.
</li>
<li data-start="1742" data-end="1884">
Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear.
</li>
<li data-start="1885" data-end="2042">
Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role.
</li>
<li data-start="2043" data-end="2197">
GLP-1s and Alzheimer&rsquo;s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people&mdash;especially APOE4 homozygotes.
</li>
</ul>
&nbsp;
TIMESTAMPS AND KEY TOPICS: <a href="https://www.youtube.com/watch?v=nevQs9cfVC0">0:00</a> &ndash; Introduction
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=408s">6:48</a> &ndash; Pathogens, toxins, and the real cause of Alzheimer&rsquo;s
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=812s">13:32</a> &ndash; Menopause, oestrogen, and female brain vulnerability
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=1445s">24:05</a> &ndash; Judy&rsquo;s story: reversing cognitive decline for 13+ years
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=1938s">32:18</a> &ndash; Most common risky behaviours for brain degeneration
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=2541s">42:21</a> &ndash; Best exercises for insulin sensitivity and cognition
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=3070s">51:10</a> &ndash; Supplements that protect brain structure &amp; function
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=3262s">54:22</a> &ndash; How to use The Ageless Brain as a practical guide
<a href="https://www.youtube.com/watch?v=nevQs9cfVC0&amp;t=3525s">58:45</a> &ndash; Final thoughts + where to learn more from Dr. Bredesen
&nbsp;
VALUABLE RESOURCES
<a href="https://angelafosterperformance.com/angela-recommends/" data-saferedirecturl="https://www.google.com/url?q=https://angelafosterperformance.com/angela-recommends/&amp;source=gmail&amp;ust=1743339104487000&amp;usg=AOvVaw2uuVwWD0gfAHAG7ClCCPwr">Click here</a> for discounts on all the products I personally use and recommend
&nbsp;
A BIG thank you to our sponsors who make the show possible:
Get 20% off the Creatine I love at <a href="https://trycreate.co/ANGELA20">trycreate.co/ANGELA20</a>, and use code ANGELA20 to save 20% on your firsts order.
Brain Boost: Try Neuro Regenerate at <a href="http://lvluphealth.com/angela">lvluphealth.com/angela</a> and use code ANGELA15 to save 15%
ABOUT THE GUEST
Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline.
Dr Dale Bredesen&rsquo;s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - <a href="thttps://amzn.eu/d/gdrjKQm">https://amzn.eu/d/gdrjKQm</a>
<a href="https://www.apollohealthco.com/">https://www.apollohealthco.com/</a>
<a href="https://www.instagram.com/drdalebredesen/">https://www.instagram.com/drdalebredesen/</a>
<a href="https://www.facebook.com/drdalebredesen/">https://www.facebook.com/drdalebredesen/</a>&nbsp; &nbsp; 
ABOUT THE HOST
Angela Foster is an award winning Nutritionist, Health &amp; Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women&rsquo;s Biohacking Conference, Livestrong &amp; Natural Health Magazine.
Angela is the creator of BioSyncing&reg;️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out.
The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. 
CONTACT DETAILS
<a href="https://www.instagram.com/angelasfoster/">Instagram</a>
<a href="http://facebook.com/angelafosterperformance">Facebook</a>
<a href="https://www.linkedin.com/in/angela-foster-/">LinkedIn</a>
Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show!
Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.
This Podcast has been brought to you by&nbsp;Disruptive Media.&nbsp;<a href="https://disruptivemedia.co.uk/" data-stringify-link="https://disruptivemedia.co.uk/" data-sk="tooltip_parent">https://disruptivemedia.co.uk/</a>

The High-Performance Health Podcast is all about optimising your body, mind and lifestyle for high performance. 

Packed full of actionable insights, strategies, bio hacks, lifestyle hacks, mindset strategies and expert performance advice, Angela Foster is on a mission to optimise your human potential. Featuring interviews with some of the top experts on the planet in the fields of health, performance and business, this show aims to inspire, educate and empower you to live an energetic, healthful and limitless life.

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