Emmy-Winning Actor and Director, Pamela Adlon

Isaac Mizrahi sits down with actor, writer, producer and director Pamela Adlon (“Better Things,” “King of the Hill,” “Californication”) They talk about why she needs a hope boner, how failure is kind of her brand, the dynamic between men and strong women and so much more. Plus, Pamela shares how w…

Interior Designer & TV Host, Jeremiah Brent

Isaac Mizrahi chats with interior designer and TV host, Jeremiah Brent (HGTV’s “The Nate & Jeremiah Home Project,” “Nate and Jeremiah: Save My House,” “Rock the Block.”) They get into whether Nate Berkus is the mean daddy or the nice daddy, the time Jeremiah was homeless, why a throuple would be st…

Podcast Host & Crooked Media Co-Founder, Jon Lovett

Isaac Mizrahi has a fun, frank and, at times, flirty conversation with podcast host and former presidential speechwriter, Jon Lovett (“Pod Save America”, “Lovett or Leave It.”) They talk about Jon’s imposter syndrome, his feelings about identifying as a gay man, being on Mounjaro and more. Plus, wh…

Actor and Director, Ashley Williams

Isaac Mizrahi talks to actor, writer, producer and director, Ashley Williams (“How I Met Your Mother,“ Hallmark Movies) about the craziest setback that led to her becoming a director, the horrible thing a cameraman once said to her and how she was inappropriate at a puppy party. Plus, they imagine …

Beloved TV Actor, Mindy Cohn

Isaac Mizrahi sits down with actor, Mindy Cohn (Facts of Life, Scooby-Doo, Palm Royale.) Mindy spills the tea on George Clooney and talks about how she and her “Facts of Life” co-stars don’t make any money on residuals. Plus, she shares the wonderful advice she got from Betty White, Bea Arthur and …

Actor and Activist, Alyssa Milano

Isaac Mizrahi chats with humanitarian and New York Times bestselling author, Alyssa Milano, about the moment that changed her life when she was 15, why she’s sworn off Botox and fillers, the most terrifying thing she’s ever done and so much much more. Follow Hello Isaac on @helloisaacpodcast on In…

Ask Isaac Part 2 with Brandon Lewis

Back by popular demand, guest host, Brandon Lewis, returns to ask Isaac Mizrahi more burning questions from his fans and Isaac doesn't hold back. He reveals the best advice he ever got from Liza Minelli, his favorite skincare regimen, what he wants (and doesn’t want) in his obituary and so much mor…

Broadway Actor & TV Star, Michael Urie

Isaac Mizrahi sits down with actor, producer, director and host, Michael Urie (Ugly Betty, Shrinking, Maestro). Michael shares the best thing that came out of his “Ugly Betty” experience, the surprising way he met his partner, why he’s forever entwined with Barbra Streisand and so much more. Follo…

“Wait Wait… Don’t Tell Me” Host, Peter Sagal

Isaac Mizrahi chats with the beloved host of NPR’s “Wait Wait… Don’t Tell Me,” Peter Sagal. Peter shares some surprising and hilarious behind-the-scenes stories, what it’s like to have a newborn at 58 and how he landed the job writing “Dirty Dancing 2: Havana Nights.” Plus, Isaac challenges Peter t…

Oscar & Emmy Award-Winning Director, Roger Ross Williams

Isaac Mizrahi sits down with director, writer and producer Roger Ross Williams (“Cassandro,” “Stamped from the Beginning” based on the book by Ibram X. Kendi.) They discuss the surprising response Roger got when he was the only Black person at a Black Lives Matter protest, why racist ideas harm eve…