Previously on Health Discovered, we learned how indolent systemic mastocytosis (ISM), a condition caused by an abnormal buildup of mast cells throughout the body, is diagnosed. Now, we’re looking at how ISM is treated and how symptoms can be managed. We speak with Tracy I. George, MD, a hematopathologist, and Jonathan A. Bernstein, MD, an allergist and immunologist, about what ISM treatments do, how to know if they’re working, what’s at risk when ISM goes unmonitored, and which symptoms should never be ignored. We also discuss the care team involved in treating ISM. Plus, ISM patient and Mast Cast Pod co-host Rachael Rose shares her experience managing symptoms and finding the right care team.

Credits 
Host: Neha Pathak, MD, FACP, DipABLM
Producer/Editor: Matt Stillo
Show Notes: Lauren Summers
Guest: Tracy I George, MD; Jonathan A. Bernstein, MD; Rachael Rose

<p dir="ltr"><a href="https://www.webmd.com/podcasts/20260709/indolent-systemic-mastocytosis-understanding-the-symptoms-and-diagnostic-journey" data-saferedirecturl="https://www.google.com/url?q=https://www.webmd.com/podcasts/20260709/indolent-systemic-mastocytosis-understanding-the-symptoms-and-diagnostic-journey&amp;source=gmail&amp;ust=1787665890753000&amp;usg=AOvVaw1OFyDznc9It48Ai3R0WRnQ">Previously</a> on Health Discovered, we learned how <a href="https://www.webmd.com/allergies/systemic-mastocytosis" data-saferedirecturl="https://www.google.com/url?q=https://www.webmd.com/allergies/systemic-mastocytosis&amp;source=gmail&amp;ust=1787665890753000&amp;usg=AOvVaw35xF5g05b7hRQIgMuC_HnR">indolent systemic mastocytosis (ISM)</a>, a condition caused by an abnormal buildup of mast cells throughout the body, is diagnosed. Now, we&rsquo;re looking at how ISM is treated and how symptoms can be managed. We speak with <a href="https://healthcare.utah.edu/find-a-doctor/tracy-i-george" data-saferedirecturl="https://www.google.com/url?q=https://healthcare.utah.edu/find-a-doctor/tracy-i-george&amp;source=gmail&amp;ust=1787665890753000&amp;usg=AOvVaw3z1Hl-tvBgDr1Qi0eb7t5R">Tracy I. George, MD</a>, a hematopathologist, and <a href="https://advancedallergyservices.com/jonathan-a-bernstein/" data-saferedirecturl="https://www.google.com/url?q=https://advancedallergyservices.com/jonathan-a-bernstein/&amp;source=gmail&amp;ust=1787665890753000&amp;usg=AOvVaw3NcVji4SZTXYTxJ22tM9EW">Jonathan A. Bernstein, MD</a>, an allergist and immunologist, about what ISM treatments do, how to know if they&rsquo;re working, what&rsquo;s at risk when ISM goes unmonitored, and which symptoms should never be ignored. We also discuss the care team involved in treating ISM. Plus, ISM patient and <a href="https://www.instagram.com/mastcastpod" data-saferedirecturl="https://www.google.com/url?q=https://www.instagram.com/mastcastpod&amp;source=gmail&amp;ust=1787665890753000&amp;usg=AOvVaw2vY-Lwn9C2zrquF9pnYnLm">Mast Cast Pod</a> co-host Rachael Rose shares her experience managing symptoms and finding the right care team.</p>
<p>Credits&nbsp;</p>
<ul>
<li aria-level="1">Host: Neha Pathak, MD, FACP, DipABLM</li>
<li aria-level="1">Producer/Editor: Matt Stillo</li>
<li aria-level="1">Show Notes: Lauren Summers</li>
<li aria-level="1">Guest: Tracy I George, MD; Jonathan A. Bernstein, MD; Rachael Rose</li>
</ul>

WebMD Chief Physician Editor Neha Pathak, MD, and Chief Medical Officer, John Whyte, MD, MPH, explore fascinating stories to find the unexpected things that help us understand our health.