Robin Carhart-Harris is one of the world's leading researchers studying psychedelics, consciousness, and mental health. For decades, psychedelics sat on the fringes of medicine. Today, they're at the center of some of the most promising research into depression, well-being, and the human mind. Robin's groundbreaking work has helped uncover how substances like psilocybin and LSD affect the brain and their potential role in treating mental illness. Robin joins Jim to explore the science behind psychedelics, what brain imaging studies reveal about consciousness, and why researchers are rethinking the treatment of depression and other mental health conditions. They discuss the role of set and setting, the differences between clinical and non-clinical use, and what the future may hold for psychedelic medicine.