Jim sits down with Dave Fredrickson, Executive Vice President of AstraZeneca's Oncology Business Unit, to explore the breakthroughs reshaping cancer care and why this may be the most promising moment in oncology history. Dave's journey has taken him from the Pentagon to consulting, Genentech, and ultimately the leadership of one of the world's largest oncology businesses. Along the way, he's helped bring some of the most important cancer innovations to patients around the world. Jim and Dave discuss what came out of ASCO, the rise of AI in healthcare, precision diagnostics, antibody-drug conjugates, cell therapy, and the growing possibility that many cancers may one day become curable. They also tackle the perception problem facing the pharmaceutical industry, why global collaboration matters more than ever, and what it takes to lead through rapid scientific change.