What are the biggest fantasy football questions heading into Week 1? Ryan Wormeli, Pat Fitzmaurice, and Derek Brown go game by game through the NFL slate, identifying the key question fantasy managers need answered in every matchup as the 2026 season gets underway.

Can Josh Allen overcome a brutal Texans defense? Is Tetairoa McMillan ready for a huge Week 1? How high can Chris Olave climb against Detroit, and is Parker Washington headed for a breakout? The crew also examines Lamar Jackson’s first game in a new offense, the outlooks for Drake London and Kyle Pitts, Marvin Harrison Jr. vs. Quentin Johnston, Michael Mayer without Brock Bowers, and the CeeDee Lamb-George Pickens target split.

Plus, what should we expect from Patrick Mahomes in his return against Denver, which offenses could struggle out of the gate, and which players could outperform consensus expectations? Get the biggest fantasy football storylines, rankings debates, matchup questions, and Week 1 predictions from across the entire NFL slate.

Timestamps: (May be off due to ads)

Week 1 Early Takeaways: CMC, 49ers & Drake Maye - 0:00:00
Bears at Panthers: Tetairoa McMillan & Jalen Coker - 0:04:13
Buccaneers at Bengals: Emeka Egbuka & Chris Godwin - 0:09:28
Saints at Lions: Chris Olave & Juwan Johnson - 0:14:30
Bills at Texans: Can You Trust Josh Allen? - 0:19:33
Ravens at Colts: Lamar Jackson vs. Jonathan Taylor - 0:25:39
Browns at Jaguars: Parker Washington Breakout Game? - 0:31:29
Falcons at Steelers: Bijan Robinson, Drake London & Kyle Pitts - 0:35:02
Titans at Jets: Week 1 Sleepers & Rankings Values - 0:38:13
Cardinals at Chargers: Marvin Harrison Jr. vs. Quentin Johnston - 0:41:02
Dolphins at Raiders: Michael Mayer Without Brock Bowers - 0:44:54
Packers at Vikings: Marshawn Lloyd vs. Jordan Mason - 0:48:58
Commanders at Eagles: Which New Offense Starts Fast? - 0:54:13
Cowboys at Giants: CeeDee Lamb vs. George Pickens - 0:56:11
Favorite Week 1 Player Props  - 0:58:55
Broncos at Chiefs: Patrick Mahomes’ Return - 1:00:05
Week 1 Final Thoughts - 1:02:55

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