When should we give fluids in sepsis?  How much?

This is a question that has troubled emergency physicians, intensivists and anaesthetists for decades.  Given how common the condition is, it is surprising that there is such a paucity of quality evidence to guide practice.

Dr Stephen McDonald is an emergency physician from Perth, Australia, and is heading up the ARISE-Fluids trial that will explore the question of whether earlier vasoconstrictor support and restriction of fluids in the early resuscitation period improves outcomes.

This interview was recorded at the 20th annual meeting of the ANZICS Clinical Trials Group in Noosa, Queensland