We welcome a foremost expert on the science of aging, lifespan, and healthspan, Professor Brian Kennedy, Distinguished Professor of Biochemistry and Physiology, National University of Singapore. In this fascinating conversation, we begin by understanding senescence, the process of functional decay of organisms. Prof Kennedy explores aging at physical and cognitive levels, and its linkage with genetics, diet, and exercise. We then delve into the scientific work going with several molecules that appear to be promising in slowing cell decay, including alpha keto-glutarate, spermidine, and the in-vouge NAD. Prof Kennedy is a keen proponent of data-driven personalised approach to medicine, seeing a great deal of promise in the application of gene therapy, stem cell therapy, and artificial intelligence. At the end, I ask him if aging is a disease that can be cured; let’s just say he has an intriguing response!