Almost two-thirds of people diagnosed with Alzheimer’s are women. Shifting hormones make us especially vulnerable. But what if there were ways to lower your risk? Preventive neurologist Dr. Richard Isaacson believes nearly half of dementia cases can be avoided. He shares how to know if you’re at risk for Alzheimer’s and what steps to take for better long-term brain health.

Links to resources mentioned in this episode:

Individualized clinical management of patients at risk for Alzheimer’s dementia

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function

A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial

evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease

Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk

Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study

The Institute for Neurodegenerative Diseases (IND)

Retain Your Brain

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

Almost two-thirds of people diagnosed with Alzheimer&rsquo;s are women. Shifting hormones make us especially vulnerable. But what if there were ways to lower your risk? Preventive neurologist Dr. Richard Isaacson believes nearly half of dementia cases can be avoided. He shares how to know if you&rsquo;re at risk for Alzheimer&rsquo;s and what steps to take for better long-term brain health.
Links to resources mentioned in this episode:
<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6925647/">Individualized clinical management of patients at risk for Alzheimer&rsquo;s dementia</a>
<a href="https://jamanetwork.com/journals/jama/article-abstract/2837046?utm_source=chatgpt.com">Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function</a>
<a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60461-5/abstract?utm_source=chatgpt.com">A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial</a>
<a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01296-0/abstract">Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission</a>
<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6188641/">Clinical Application of APOE in Alzheimer's Prevention: A Precision Medicine Approach</a>
<a href="https://www.nature.com/articles/s41598-021-90084-y">Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition</a>
<a href="https://www.neurology.org/doi/10.1212/WNL.0000000000012941">Association of Reproductive History With Brain MRI Biomarkers of Dementia Risk in Midlife</a>
<a href="https://jamanetwork.com/journals/jama/fullarticle/2723256">Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial</a>
<a href="https://pubmed.ncbi.nlm.nih.gov/39780249/">evoke and evoke+: design of two large-scale, double-blind, placebo-controlled, phase 3 studies evaluating efficacy, safety, and tolerability of semaglutide in early-stage symptomatic Alzheimer's disease</a>
<a href="https://pubmed.ncbi.nlm.nih.gov/36281678/">Sex-Driven Differences in the Effectiveness of Individualized Clinical Management of Alzheimer's Disease Risk</a>
<a href="https://pubmed.ncbi.nlm.nih.gov/32580974/">Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study</a>
<a href="https://ind.org/learn">The Institute for Neurodegenerative Diseases (IND)</a>
<a href="https://retainyourbrain.com/#!/">Retain Your Brain</a>
Note: In this show, we use &ldquo;women&rdquo; as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

Why is it still so hard for women to find reliable, modern health information about their own bodies? On Decoding Women's Health, Dr. Elizabeth Poynor, chair of women’s health & gynecology at the Atria Health Institute, shares expert insights on women’s health, hormones, and longevity science to help you thrive at any stage of midlife and beyond.

Dr. Poynor, a world-renowned gynecologic oncologist and advanced pelvic surgeon, speaks with leading physicians, researchers, and educators to share the latest science on women’s wellness, disease prevention, and what it really means to age on your own terms. Each episode explores a different aspect of how to improve your health during midlife—from heart disease and genetic risks to metabolism, hormones nutrition, cognitive health, and beyond.

Whether you're in perimenopause, postmenopause, or simply looking for tools to prepare for the next chapter, take charge of your health—now and for the future—with expert guidance and practical advice to help you thrive. 

Why is it still so hard for women to find reliable, modern health information about their own bodies? On Decoding Women's Health, Dr. Elizabeth Poynor, chair of women&rsquo;s health &amp; gynecology at the Atria Health Institute, shares expert insights on women&rsquo;s health, hormones, and longevity science to help you thrive at any stage of midlife and beyond.
Dr. Poynor, a world-renowned gynecologic oncologist and advanced pelvic surgeon, speaks with leading physicians, researchers, and educators to share the latest science on women&rsquo;s wellness, disease prevention, and what it really means to age on your own terms. Each episode explores a different aspect of how to improve your health during midlife&mdash;from heart disease and genetic risks to metabolism, hormones nutrition, cognitive health, and beyond.
Whether you're in perimenopause, postmenopause, or simply looking for tools to prepare for the next chapter, take charge of your health&mdash;now and for the future&mdash;with expert guidance and practical advice to help you thrive.&nbsp;

Decoding Women's Health with Dr. Elizabeth Poynor

Decoding Dementia Prevention with Dr. Richard Isaacson

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/52360ea8-4b03-4a0e-980c-b3a60159c6a0/transcript

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