For nearly half of all breast cancer patients – those with low levels of the HER2 protein – targeted treatment options have always been limited. Palliative chemo has been the standard of care in stage 4 metastatic patients – until now. In this episode, Dr. Diane Reidy-Lagunes talks with Dr. Shanu Modi, the lead researcher of a groundbreaking MSK trial that proved a drug that combines an antibody with a chemotherapy – trastuzumab deruxtecan (T-DXd) – can control cancer cells and extend survival in stage 4 HER2-low breast cancer patients. With a fresh FDA approval, T-DXd is now being tested on other cancers and changing the way oncologists treat their patients.

For nearly half of all <a href="https://www.mskcc.org/cancer-care/types/breast">breast cancer</a> patients – those with low levels of the HER2 protein – targeted treatment options have always been limited. Palliative chemo has been the standard of care in stage 4 metastatic patients – until now. In this episode, <a href="https://www.mskcc.org/cancer-care/doctors/diane-reidy-lagunes">Dr. Diane Reidy-Lagunes</a> talks with <a href="https://www.mskcc.org/cancer-care/doctors/shanu-modi">Dr. Shanu Modi</a>, the lead researcher of a <a href="https://www.mskcc.org/news-releases/asco-2022-practice-changing-findings-identify-her2-low-targetable-subset-breast-cancer-redefining-treatment-more-60-percent-her2-negative-metastatic-breast-cancer-patients">groundbreaking MSK trial</a> that proved a drug that combines an antibody with a chemotherapy – trastuzumab deruxtecan (<a href="https://www.mskcc.org/cancer-care/patient-education/fam-trastuzumab-deruxtecan">T-DXd</a>) – can control cancer cells and extend survival in stage 4 HER2-low breast cancer patients. With a fresh FDA approval, T-DXd is now being tested on other cancers and changing the way oncologists treat their patients.

Cancer Straight Talk from Memorial Sloan Kettering Cancer Center brings together national experts and cancer patients to have straightforward, evidence-based conversations. Our mission is to educate and empower patients and their families to make the right decisions and live happier, healthier lives.

Cancer Straight Talk from Memorial Sloan Kettering Cancer Center brings together national experts and cancer patients to have straightforward, evidence-based conversations. Our mission is to educate and empower patients and their families to make the right decisions and live happier, healthier lives.

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