Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain – they’re investigating potential non-opioid based treatment options that aim to target pain differently.

This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain &ndash; they&rsquo;re investigating potential non-opioid based treatment options that aim to target pain differently.
This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

Listen for today's top stories, with context, in just 15 minutes. 

Each morning, hosts Nathan Hager and Karen Moskow bring you the latest on US politics, foreign relations, business, financial markets and global economics. The show is recorded at 5 AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Listen for today's top stories, with context, in just 15 minutes. Each morning, hosts Nathan Hager and Karen Moskow bring you the latest on US politics, foreign relations, business, financial markets and global economics. The show is recorded at 5 AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Bloomberg Daybreak: US Edition

Listen for today's top stories, with context, in just 15 minutes. 

Each morning, hosts Nathan Hager and Karen Moskow bring you the latest headlines on US politics, foreign relations, financial markets and global economics. The show is recorded at 5AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Listen for today's top stories, with context, in just 15 minutes. Each morning, hosts Nathan Hager and Karen Moskow bring you the latest headlines on US politics, foreign relations, financial markets and global economics. The show is recorded at 5AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Targeting Pain (Sponsored Content)

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/66772d5f-f50b-4f8c-b89e-b2f400fee526/transcript

Today's top stories, with context, in just 15 minutes.   

On today's podcast:   

1) The Supreme Court refused to clear the Postal Service to enforce new restrictions on mail-in ballots for the congressional midterm elections, rebuffing the Trump administration’s request to intervene. The court denied the Justice Department’s request to lift a Boston federal judge’s order that barred the Postal Service from making its new mail-in ballot rules mandatory through the November contests. The Supreme Court's decision means that the Postal Service cannot enforce the new rules for the midterms, but the legal fight over whether the agency can ultimately adopt the rules for future election cycles may still continue.   

2) The 10-year US Treasury yield rose to the highest in almost two decades, driven by surging energy prices, mounting debt and inflation. The yield on the global bond benchmark rose to 5.02% on Tuesday, surpassing a peak from 2023 to hit the highest since 2007. The pressure in the bond market raises the stakes ahead of the Federal Reserve’s interest-rate decision, where investors expect officials to raise short-term borrowing costs for the first time since July 2023.   

3) President Trump's opposition to guardrails on artificial intelligence puts him at odds with lawmakers from both parties who have AI safety fears. Trump belittled a push led by Anthropic PBC and OpenAI to slow work on cutting-edge systems, dismissing existential fears about AI as "a hoax." Lawmakers are working on legislation aimed at addressing AI safety concerns, including a bipartisan group of senators who are working on legislation requiring top AI developers to prevent catastrophic risks.Eric Mollo

Today's top stories, with context, in just 15 minutes.&nbsp; &nbsp; On today's podcast:&nbsp; &nbsp; 1) The Supreme Court refused to clear the Postal Service to enforce new restrictions on mail-in ballots for the congressional midterm elections, rebuffing the Trump administration&rsquo;s request to intervene. The court denied the Justice Department&rsquo;s request to lift a Boston federal judge&rsquo;s order that barred the Postal Service from making its new mail-in ballot rules mandatory through the November contests. The Supreme Court's decision means that the Postal Service cannot enforce the new rules for the midterms, but the legal fight over whether the agency can ultimately adopt the rules for future election cycles may still continue.&nbsp; &nbsp; 2) The 10-year US Treasury yield rose to the highest in almost two decades, driven by surging energy prices, mounting debt and inflation. The yield on the global bond benchmark rose to 5.02% on Tuesday, surpassing a peak from 2023 to hit the highest since 2007. The pressure in the bond market raises the stakes ahead of the Federal Reserve&rsquo;s interest-rate decision, where investors expect officials to raise short-term borrowing costs for the first time since July 2023.&nbsp; &nbsp; 3) President Trump's opposition to guardrails on artificial intelligence puts him at odds with lawmakers from both parties who have AI safety fears. Trump belittled a push led by Anthropic PBC and OpenAI to slow work on cutting-edge systems, dismissing existential fears about AI as "a hoax." Lawmakers are working on legislation aimed at addressing AI safety concerns, including a bipartisan group of senators who are working on legislation requiring top AI developers to prevent catastrophic risks.Eric Mollo

Trump Mail-In Request Rejected; Obama Weighs In on AI

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/c87d9248-60f5-48ce-b70a-b4c6009d28b1/transcript

Today's top stories, with context, in just 15 minutes.
On today's podcast:
1) Anthropic and OpenAI are promising measures to rein in the pursuit of cutting-edge AI models to better understand the risks posed by the technology following a series of security breaches. The two companies' calls to slow down AI development may be resisted by forces in the tech industry, financial markets, and the Trump administration, which has staked its economic agenda on aggressive AI advancement. Anthropic CEO Dario Amodei has proposed opening the company's doors to third-party evaluators to review new systems before their release, and OpenAI CEO Sam Altman has said he likes the idea and plans to implement it at his company.
2) Oil prices rose after Saudi Arabia closed a major crude pipeline following attacks, disrupting a key route that bypasses the Strait of Hormuz. The closure may lead to output cuts if it is prolonged, according to June Goh, senior oil market analyst at Sparta Commodities SA. A meeting between Iran and several Gulf nations on creating a temporary shipping lane through Hormuz was postponed, amid a rapid military advance by Iranian-backed Houthi militants in Yemen.
3) The Fed faces pressure to hike interest rates to tame elevated inflation, which puts Chair Kevin Warsh on a collision course with President Trump, who has pressed the central bank to slash rates. Trump has repeatedly argued that US borrowing costs should be the lowest in the world, and a rate hike could lead to a public rebuke from the president, damaging Warsh's credibility. Warsh is trapped in an institutional vise, where he must balance the Fed's independence with the president's pressure, and a decision to hike or hold rates could have consequences for inflation and the administration's economic goals.

Today's top stories, with context, in just 15 minutes. On today's podcast: 1) Anthropic and OpenAI are promising measures to rein in the pursuit of cutting-edge AI models to better understand the risks posed by the technology following a series of security breaches. The two companies' calls to slow down AI development may be resisted by forces in the tech industry, financial markets, and the Trump administration, which has staked its economic agenda on aggressive AI advancement. Anthropic CEO Dario Amodei has proposed opening the company's doors to third-party evaluators to review new systems before their release, and OpenAI CEO Sam Altman has said he likes the idea and plans to implement it at his company. 2) Oil prices rose after Saudi Arabia closed a major crude pipeline following attacks, disrupting a key route that bypasses the Strait of Hormuz. The closure may lead to output cuts if it is prolonged, according to June Goh, senior oil market analyst at Sparta Commodities SA. A meeting between Iran and several Gulf nations on creating a temporary shipping lane through Hormuz was postponed, amid a rapid military advance by Iranian-backed Houthi militants in Yemen. 3) The Fed faces pressure to hike interest rates to tame elevated inflation, which puts Chair Kevin Warsh on a collision course with President Trump, who has pressed the central bank to slash rates. Trump has repeatedly argued that US borrowing costs should be the lowest in the world, and a rate hike could lead to a public rebuke from the president, damaging Warsh's credibility. Warsh is trapped in an institutional vise, where he must balance the Fed's independence with the president's pressure, and a decision to hike or hold rates could have consequences for inflation and the administration's economic goals.

AI Leaders Warn of Catastrophic Harm; Tech Stocks Slide in Response

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/c77e0a40-088c-431f-93f9-b4c5009df1cc/transcript

Bloomberg Daybreak Weekend with Host Nathan Hager take a look at some of the stories we'll be tracking in the coming week.
In the US – a look ahead to the next FOMC decision, along with a focus on 3 stocks for the week ahead.
In the UK – a look ahead to Sweden’s general election.
In Asia – a look ahead to the next monetary policy decision from the Bank of Japan.

Bloomberg Daybreak Weekend with Host Nathan Hager take a look at some of the stories we'll be tracking in the coming week.
<ul>
<li>In the US &ndash; a look ahead to the next FOMC decision, along with a focus on 3 stocks for the week ahead.</li>
<li>In the UK &ndash; a look ahead to Sweden&rsquo;s general election.</li>
<li>In Asia &ndash; a look ahead to the next monetary policy decision from the Bank of Japan.</li>
</ul>

 Daybreak Weekend: Fed Decision, Sweden Election, BOJ Meeting

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/37b7a421-a609-4c33-9b40-b4c2013fe643/transcript

Targeting Pain (Sponsored Content)

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