Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain – they’re investigating potential non-opioid based treatment options that aim to target pain differently.

This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

Damian Sanchez, (Damian J to music fans) is a Miami-based jazz musician. A car accident landed him in the hospital with multiple fractures to his leg. Once there, he faced the difficult decision of whether or not to take the pain medication that was offered to him. With patients like Damian in mind, Dr. Paul Negulescu and the research team at Vertex are thinking differently about pain &ndash; they&rsquo;re investigating potential non-opioid based treatment options that aim to target pain differently.
This episode of Targeting the Toughest Diseases is sponsored by Vertex Pharmaceuticals.

Listen for today's top stories, with context, in just 15 minutes. 

Each morning, hosts Nathan Hager and Karen Moskow bring you the latest headlines on US politics, foreign relations, financial markets and global economics. The show is recorded at 5AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Listen for today's top stories, with context, in just 15 minutes. Each morning, hosts Nathan Hager and Karen Moskow bring you the latest headlines on US politics, foreign relations, financial markets and global economics. The show is recorded at 5AM ET each weekday, so you get the freshest reporting on the stories that matter. Get informed from Bloomberg's 3,000 journalists and analysts. Listen and subscribe to Bloomberg Daybreak: US Edition.

Bloomberg Daybreak: US Edition

Targeting Pain (Sponsored Content)

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/66772d5f-f50b-4f8c-b89e-b2f400fee526/transcript

On today's podcast:
1) While both the US and Iran have sounded cautiously upbeat about the latest round of diplomatic talks between the nations, analysts believe that strikes on Iranian targets remain a likely possibility. The US has amassed military assets in the Middle East and has dispatched a second aircraft carrier to the region. Concerns of a broader conflict held Brent crude above $70 a barrel. The US also announced new visa restrictions, with the State Department saying it is targeting 18 Iranian officials and telecommunications industry leaders and their immediate family members for the crackdown and communications blackout, blaming them for “inhibiting the right of Iranians to free expression and peaceful assembly.”
2) Billionaire retail tycoon Leslie Wexner told a US House panel Wednesday that he visited Jeffrey Epstein’s private Caribbean island but said at the time he wasn’t aware of any sex trafficking operation involving the disgraced financier. Wexner said he went to the island once with his wife and children “for a few hours” while the family was in the area on their boat, according to his opening statement in a deposition to congressional investigators that was provided to Bloomberg News by his attorney. The House Oversight Committee has been investigating what role Epstein’s broad network of connections may have played in facilitating his enterprise or delaying criminal prosecution. Wexner was questioned behind closed doors by congressional investigators for six hours on Wednesday, a spokesman for the panel said.
3) OpenAI is close to finalizing the first phase of a new funding round that is likely to bring in more than $100 billion, according to people familiar with the matter, a record-breaking financing deal that would give the startup additional capital to build out its artificial intelligence tools. As the ChatGPT maker prepares to spend trillions in infrastructure investment, the overall valuation of the company, including the eventual funding, could exceed $850 billion, according to some of the people. That’s higher than the $830 billion initially expected. The company’s pre-money value will remain $730 billion, said one person, all of whom asked not to be identified discussing private information.

On today's podcast: 1) While both the US and Iran have sounded cautiously upbeat about the latest round of diplomatic talks between the nations, analysts believe that strikes on Iranian targets remain a likely possibility. The US has amassed military assets in the Middle East and has dispatched a second aircraft carrier to the region. Concerns of a broader conflict held Brent crude above $70 a barrel. The US also announced new visa restrictions, with the State Department saying it is targeting 18 Iranian officials and telecommunications industry leaders and their immediate family members for the crackdown and communications blackout, blaming them for &ldquo;inhibiting the right of Iranians to free expression and peaceful assembly.&rdquo; 2) Billionaire retail tycoon&nbsp;Leslie Wexner&nbsp;told a US House panel Wednesday that he visited&nbsp;Jeffrey Epstein&rsquo;s private Caribbean island but said at the time he wasn&rsquo;t aware of any sex trafficking operation involving the disgraced financier. Wexner said he went to the island once with his wife and children &ldquo;for a few hours&rdquo; while the family was in the area on their boat, according to his opening statement in a deposition to congressional investigators that was provided to Bloomberg News by his attorney. The&nbsp;House Oversight Committee&nbsp;has been investigating what role Epstein&rsquo;s broad network of connections may have played in facilitating his enterprise or delaying criminal prosecution. Wexner was questioned behind closed doors by congressional investigators for six hours on Wednesday, a spokesman for the panel said. 3) OpenAI&nbsp;is close to finalizing the first phase of a new funding round that is likely to bring in more than $100 billion, according to people familiar with the matter, a record-breaking financing deal that would give the startup additional capital to build out its artificial intelligence tools.&nbsp;As the ChatGPT maker prepares to&nbsp;spend trillions&nbsp;in infrastructure investment, the overall valuation of the company, including the eventual funding, could exceed $850 billion, according to some of the people. That&rsquo;s higher than the $830 billion initially expected. The company&rsquo;s pre-money value will remain $730 billion, said one person, all of whom asked not to be identified discussing private information.

US Ratchets Up Iran Pressure; OpenAI Funding to Top $100 Billion

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/c70c7625-0483-4f77-88e1-b3f600ae531b/transcript

Today's top stories, with context, in just 15 minutes.
On today's podcast:
1) The US and Iran made progress in nuclear talks in Geneva on Tuesday, with Tehran’s negotiators scheduled to return with a new proposal in two weeks, a US official said on Tuesday, a cautiously upbeat assessment that suggests the chances of an imminent military clash are low. The official, who asked not to be named, said Iran would return with detailed proposals to address the remaining gaps between the two sides, but cautioned that there were still a lot of details to discuss. In an earlier statement, Iran said it had reached a “general agreement” with the US on the terms of a potential nuclear deal that would lift sanctions on Tehran and ease the risk of a broader war in the Middle East. But from the outset, there was also confusion between the US and Iranian sides on the scope of the negotiations, with President Trump bringing Tehran to the talks under the threat of US airstrikes.
2) Ukraine and Russia began a second day of US-brokered talks in Geneva after Kyiv’s lead negotiator held separate meetings with American and European allies to coordinate their approach. “Consultations are taking place in groups focusing on specific areas within the political and military blocs,” Ukrainian National Security and Defense Council Secretary Rustem Umerov said Wednesday on Telegram. Russian media also reported that the negotiations had resumed behind closed doors. Umerov on Tuesday said he’d met with representatives of the US, France, the UK, Germany, Italy and Switzerland. “It’s important to maintain a common vision and coordination of actions between Ukraine, the US and Europe,” he said after the meetings in a post on Telegram. “There is an understanding of shared responsibility for the outcome.”
3) Japan plans to invest up to $36 billion in US oil, gas and critical mineral projects, the first tranche of its $550 billion commitment under the trade agreement it struck with President Trump. Japanese Prime Minister Sanae Takaichi said the projects were designed to build resilient supply chains through cooperation in areas crucial for economic security, including critical minerals, energy and artificial intelligence. The most significant investment is a natural gas facility in Ohio that’s expected to generate 9.2 gigawatts of power, according to a statement from US Commerce Secretary Howard Lutnick, a massive project which Trump described as “the largest in History.”

Today's top stories, with context, in just 15 minutes. On today's podcast: 1) The US and Iran made progress in nuclear talks in Geneva on Tuesday, with Tehran&rsquo;s negotiators scheduled to return with a new proposal in two weeks, a US official said on Tuesday, a cautiously upbeat assessment that suggests the chances of an imminent military clash are low. The official, who asked not to be named, said Iran would return with detailed proposals to address the remaining gaps between the two sides, but cautioned that there were still a lot of details to discuss. In an earlier statement, Iran said it had reached a &ldquo;general agreement&rdquo; with the US on the terms of a potential nuclear deal that would lift sanctions on Tehran and ease the risk of a broader war in the Middle East. But from the outset, there was also confusion between the US and Iranian sides on the scope of the negotiations, with President Trump bringing Tehran to the talks under the threat of US airstrikes. 2) Ukraine and Russia began a second day of US-brokered talks in Geneva after Kyiv&rsquo;s lead negotiator held separate meetings with American and European allies to coordinate their approach. &ldquo;Consultations are taking place in groups focusing on specific areas within the political and military blocs,&rdquo; Ukrainian National Security and Defense Council Secretary Rustem Umerov said Wednesday on Telegram. Russian media also reported that the negotiations had resumed behind closed doors. Umerov on Tuesday said he&rsquo;d met with representatives of the US, France, the UK, Germany, Italy and Switzerland. &ldquo;It&rsquo;s important to maintain a common vision and coordination of actions between Ukraine, the US and Europe,&rdquo; he said after the meetings in a post on Telegram. &ldquo;There is an understanding of shared responsibility for the outcome.&rdquo; 3) Japan plans to invest up to $36 billion in US oil, gas and critical mineral projects, the first tranche of its $550 billion commitment under the trade agreement it struck with President Trump. Japanese Prime Minister Sanae Takaichi said the projects were designed to build resilient supply chains through cooperation in areas crucial for economic security, including critical minerals, energy and artificial intelligence. The most significant investment is a natural gas facility in Ohio that&rsquo;s expected to generate 9.2 gigawatts of power, according to a statement from US Commerce Secretary Howard Lutnick, a massive project which Trump described as &ldquo;the largest in History.&rdquo;

US & Iran Hail Progress; Ukraine and Russia Resume Talks

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/6b621674-c659-4ea2-b694-b3f500ae3c43/transcript

Today's top stories, with context, in just 15 minutes.

On today's podcast:
1) The Reverend Jesse Jackson, the civil rights leader who marched alongside Martin Luther King Jr. and later ran for president, has died at 84, according to a statement from his family released early Tuesday. Ordained in 1968, he spent decades fighting for voting rights and economic justice. A longtime advocate for racial and economic justice, Jackson was with King in Memphis in 1968 when King was assassinated. He went on to found the Rainbow PUSH Coalition and became one of the most prominent voices in American civil rights and politics.
2) Iran and the US are set to meet for a second round of nuclear talks in Switzerland on Tuesday morning as they seek to avoid renewed conflict in the Middle East following last year’s attacks on the Islamic Republic. Oman will mediate the negotiations in Geneva almost two weeks after the first round was held on February 6th, Iran’s state broadcaster said. Iranian officials have expressed willingness to discuss their nuclear-enrichment activities, but have tied any concessions to the potential easing of American sanctions. Meanwhile, Washington is increasing its military presence in the Middle East, deploying a second aircraft carrier to the region amid warnings of a possible strike on Iran if talks — which could drag on for weeks — fail to produce a compromise. Iran’s Islamic Revolutionary Guard Corps held drills around the strategic Strait of Hormuz on Monday that were focused on delivering a “decisive” response to security threats.
3) Secretary of State Marco Rubio said Europe’s fate is intertwined with the US while faulting the continent for what he said was a drift away from their shared Western values. “We want Europe to prosper because we’re interconnected in so many different ways, and because our alliance is so critical,” Rubio told Bloomberg News Editor-in-Chief John Micklethwait on the sidelines of the conference on Saturday. “But it has to be an alliance of allies that are capable and willing to fight for who they are and what’s important.”

Today's top stories, with context, in just 15 minutes. On today's podcast: 1) The Reverend Jesse Jackson, the civil rights leader who marched alongside Martin Luther King Jr. and later ran for president, has died at 84, according to a statement from his family released early Tuesday. Ordained in 1968, he spent decades fighting for voting rights and economic justice. A longtime advocate for racial and economic justice, Jackson was with King in Memphis in 1968 when King was assassinated. He went on to found the Rainbow PUSH Coalition and became one of the most prominent voices in American civil rights and politics. 2) Iran and the US are set to meet for a second round of nuclear talks in Switzerland on Tuesday morning as they seek to avoid renewed conflict in the Middle East following last year&rsquo;s attacks on the Islamic Republic. Oman will mediate the negotiations in Geneva almost two weeks after the first round was held on February 6th, Iran&rsquo;s state broadcaster said. Iranian officials have expressed willingness to discuss their nuclear-enrichment activities, but have tied any concessions to the potential easing of American sanctions. Meanwhile, Washington is&nbsp;increasing&nbsp;its military presence in the Middle East, deploying a second aircraft carrier to the region amid warnings of a possible strike on Iran if talks &mdash; which could drag on for weeks &mdash; fail to produce a compromise. Iran&rsquo;s Islamic Revolutionary Guard Corps held drills around the strategic Strait of Hormuz on Monday that were focused on delivering a &ldquo;decisive&rdquo; response to security threats. 3) Secretary of State Marco Rubio said Europe&rsquo;s fate is intertwined with the US while faulting the continent for what he said was a drift away from their shared Western values. &ldquo;We want Europe to prosper because we&rsquo;re interconnected in so many different ways, and because our alliance is so critical,&rdquo; Rubio told Bloomberg News Editor-in-Chief John Micklethwait on the sidelines of the conference on Saturday. &ldquo;But it has to be an alliance of allies that are capable and willing to fight for who they are and what&rsquo;s important.&rdquo;

Jesse Jackson Dies; Iran & US Meet for Nuclear Talks

https://api.omny.fm/orgs/e73c998e-6e60-432f-8610-ae210140c5b1/clips/052f1afd-5e5c-46c2-bf32-b3f400af82a7/transcript

Targeting Pain (Sponsored Content)

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