Week 1 is rapidly approaching! Ryan Wormeli and Andrew Erickson break down the early betting lines for the opening week of the 2026 NFL season, giving you their favorite NFL Week 1 picks, best bets, upset predictions, spreads, totals, moneyline plays and more.

Which early NFL lines offer the most value? The guys go game-by-game through the Week 1 slate, looking for opportunities to grab closing line value (CLV) before the market moves.

Some of the biggest debates include whether the Rams-49ers Australia matchup is screaming UNDER, why Houston could upset Buffalo, whether Jacksonville belongs in your Week 1 survivor pool, a Dolphins-Raiders upset pick, and whether Denver can knock off Patrick Mahomes and Kansas City at Arrowhead.

Timestamps: (May be off due to ads)

Intro - 0:00:00

Patriots @ Seahawks - 0:02:50

49ers @ Rams - 0:05:20

Bears @ Panthers - 0:08:07

Buccaneers @ Bengals - 0:10:10

Saints @ Lions - 0:14:04

BettingPros Premium Giveaway - 0:16:21

Bills @ Texans - 0:16:41

Ravens @ Colts - 0:19:45

Browns @ Jaguars - 0:23:52

Falcons @ Steelers - 0:26:39

Jets @ Titans - 0:29:43

BettingPros App - 0:31:32

Cardinals @ Chargers - 0:31:45

Dolphins @ Raiders - 0:35:16

Packers @ Vikings - 0:38:01

Commanders @ Eagles - 0:40:58

Cowboys @ Giants - 0:43:19

Broncos @ Chiefs - 0:46:14

Outro - 0:49:51

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